Freedom of Information Summary: NADA 141-251. Owners reported the following signs in their dogs after application of Advantage Multifor Dogs: pruritus, flaky/greasy residue at the treatment site, medicinal odor, lethargy, inappetence, and hyperactivity. How long does Advantage® II for dogs take to work? or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Unlike chewable forms of flea prevention, Advantage® II is applied topically and kills flea eggs, flea larvae and adult fleas through contact with your treated dog. One dog showed signs of treatment site irritation after application. Keep in mind that more frequent bathing may keep the product from working the full 30 days. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Your dog is free to take a dip after Advantage. The chemical name for imidacloprid is 1-[(6-Chloro-3- pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Healthy, active people already take a multi-vitamin, a multi-mineral, or a multi-enzyme. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Do not dispense dose applicator tubes without complete safety and administration information. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. For Skin For the first 30 minutes after application: Ensure that dogs cannot lick the product from 4. Advantage spot-on flea treatment for cats contains an active ingredient that works fast, and is able to kill fleas through contact. Your dog is free to take a dip after Advantage® II has been on for 24 hours. Once-a-month topical solution for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of intestinal parasite infections in dogs and puppies that are at least 7 weeks of age and that weigh at least 3 lbs. Advantage flea treatment for dogs is an easy-to-apply spot-on treatment that kills fleas within one day, preventing further infestations for up to four weeks. other pets to reduce the risk of accidental ingestion. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. So fleas do not have to bite your dog to die. Advantage Multi™ for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Kills fleas through contact, so fleas don't have to bite your dog to die. Dogs 11-20 pounds – 1.0 ml (Advantage Multi can use this same chart but for dogs only) Dogs 21-55 pounds – 2.5 ml. The signs in this dog may have been related to peak serum levels of moxidectin, which vary between dogs, and occur between 1 and 21 days after application of Advantage Multi for Dogs. While holding the tube in an upright position, remove the cap from the tube. (See WARNINGS.). HOW LONG DOES A DOSE LAST? And with Advocate or Advantage-Multi it may be a “topical” but it goes thru the skin **to** the bloodstream to work. For someone who unfortunately has health challenges, glandulars provide nutrients not found in plants and they don’t create any negative reaction that could occur from taking plant material. How long does Advantage® II for dogs last? One dog exhibited shaking (nervousness) 1 hour post-dosing. Box 390 Shawnee Mission, Kansas 66201 U.S.A. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. Use Advantage® II for dogs monthly, year-round to help keep your pet protected from fleas. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Do not get in eyes or on clothing. First you need to set up an account with us, create a payment method, and send us your prescriptions. Available for Android and iOS devices. Pull the cap off the tube. Thread Starter Thread Starter #3 cocheezie Dermal Safety Study in Ivermectin-Sensitive Collies:Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. Do not induce vomiting unless told to do so by the poison control center or physician. Part the hair on your dog’s back, between the shoulder blades, until the skin is visible. Advantage is a spot-on solution that is easy to apply and kills fleas on contact, so fleas don’t have to bite to die. And by killing eggs and larvae, you can break the flea life cycle. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. More on Flea Treatments Remove one dose applicator tube (tube) from the package. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. 3. It's easy to apply as long as you follow instructions carefully. Follow label directions for application. Learn how to apply this easy-to-use, odorless topical for dogs once per month to prevent fleas, flea larvae, flea eggs and chewing lice. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. Information about how quickly a medication starts to work is easily available by reading the product label, visiting the manufacturer’s website, or by talking to your veterinarian. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. CAUTION: Federal (U.S.A.) law restricts Advantage Multi ® for Dogs to use by or on the order of a licensed veterinarian.. Do not have contact or allow children to have contact with the area treated with Advantage. Avoid contact with skin. 1. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Advantage Flea Treatment remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Shampooing 90 minutes after treatment does not reduce the effectiveness of Advantage Multi for Dogs in the prevention of heartworm disease. Do not allow the dog to lick any of the application sites for. Bayer HealthCare LLC Animal Health Division. (See CONTRAINDICATIONS.). The formula kills fleas within 24 hours and … 1. Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local discomfort, and discoloration of the hair at the application site. Increased RBC, hemoglobin, activated partial thromboplastin, and direct bilirubin were observed in the treated group. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. Well, I got the Advantage for them, and the flea pill, and they had them about 5 days ago. Imidacloprid attacks the flea’s nervous system — paralyzing and ultimately killing it. If the dog is already infested with fleas when the first dose of Advantage Multi for Dogs is administered, adult fleas on the dog will be killed. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. Store at temperatures between 4°C (39°F) and 25°C (77°F), avoiding excess heat or cold. Whether this actually occurs to a moderately high degree (70-80% flea kills at 28 days) or a really high degree (>90% flea kills at 28 days), however, depends on the study you look at. Puppies younger than 7 weeks of age and pregnant dogs should not use Advantage. Wash hands thoroughlywith soap and warm water after handling. This is true even after baths or swimming, as the Advantage products are waterproof. A single application of Advantage® II for dogs stops biting fleas for one month. 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